Compounded semaglutide dose schedule: what to expect
Updated October 17, 2026
Semaglutide is started at a low dose and increased gradually. Going slowly gives your body time to adjust, which helps keep side effects like nausea manageable.
A typical schedule
Your provider sets your dose. Many plans follow a pattern like this, with each step lasting about four weeks:
| Weeks | Weekly dose |
|---|---|
| 1 to 4 | 0.25 mg |
| 5 to 8 | 0.5 mg |
| 9 to 12 | 1 mg |
| 13 to 16 | 1.7 mg |
| 17 and after | 2.4 mg |
Not everyone moves up on this timeline. Some people stay at a dose longer, and some never need the highest dose. That’s normal.
The first month
The 0.25 mg starting dose is mainly about getting used to the medication. Many people notice changes in appetite early on, but the starting dose isn’t meant to be your long-term dose.
When side effects get in the way
Nausea, constipation and other stomach side effects are most common in the first weeks and after each dose increase. If they’re hard to manage, message your care team. Your provider may keep you at your current dose longer before increasing.
Eating smaller meals, stopping when you feel full, and drinking enough water can help.
Measure carefully
Compounded semaglutide may come in a different concentration than products you’ve used before. Always follow the dosing instructions from your provider and pharmacy, and ask your care team if anything is unclear.
Price at every dose
At Sliver, your monthly price for compounded semaglutide stays the same at every dose after your first month.
This guide is general information, not medical advice. Talk to your provider about your own treatment.